Super Omega-3 EPA/DHA with Sesame Lignans & Olive Fruit Extract

The body needs fatty acids to survive and is able to make all but two of them: linoleic acid (LA), in the omega-6 family, and alpha-linolenic acid (ALA) in the omega-3 family. These two fatty acids must be supplied by the diet and are therefore considered essential fatty acids (EFAs).

Omega-3 fatty acids, found in cold-water fish (and fish oil), perilla and flaxseed oils, are essential elements of a healthy diet. Fish oils contain the essential fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are usually lacking in the typical Western diet, which is filled with foods containing high amounts of omega-6 fats.23 EPA and DHA can be synthesized in the body from ALA, but EPA and DHA synthesis may be insufficient under certain conditions and for most people that consume Western diets.

While the polyunsaturated fats known as omega-6 fatty acids are essential to life, most Americans and citizens of other Western nations consume far too many omega-6 polyunsaturated fatty acids and not enough omega-3 polyunsaturated fatty acids. In fact, some Western diets consist of 20 parts of omega-6 to only one part of omega-3. For optimum health, the ratio of omega-6 to omega-3 fatty acids should be between 1:1 and 4:1.25 The severe imbalance that occurs with most people contributes to the development of long-term health problems.

Studies associate the Mediterranean diet — rich in omega-3 fatty acids, monounsaturated fatty acids such as that found in olive oil, and antioxidant-rich fruits, vegetables, and herbs — with lowered cardiovascular risk and increased life span.26-32 Other studies support omega-3’s importance in cardiovascular health.33,34

Life Extension’s Super Omega-3 is a premium, scientifically-validated fish oil concentrate, derived from sustainable sources, that contains a proprietary, full-spectrum blend of synergistic nutrients to provide scientifically-validated cardioprotective health benefits.

An abundance of scientific research substantiates the wide-ranging health benefits of omega-3 fatty acids in fish oil and monounsaturated fatty acid and polyphenols in olive fruit.35-43 No other commercially available fish oil supplement contains this level of essential fatty acids, sesame lignans and olive fruit polyphenols.

Super Omega-3 from Life Extension uses a patented EPA/DHA extraction process that results in a pure, stable and easy-to-tolerate fish oil extract. While most fish oil is distilled to decrease contaminants such as mercury and PCBs, the Pure+™ fish oil used in Super Omega-3 is produced with a patented method that purifies the oil with a highly advanced distillation process to reduce pollutants to virtually undetectable levels. The result is an improved fish oil that exceeds the standards set by international rating agencies.

The unstable nature of fatty acids like fish oil limits their biological efficacy in the body. Scientific studies show that when sesame lignans are supplemented with fish oil, the beneficial effects are augmented.44

Sesame lignans help guard against lipid peroxidation, thereby extending the stability of DHA in the body. These lignans also direct fatty acids toward pathways which can help with inflammatory reactions. Super Omega-3 provides standardized sesame lignans to enhance the overall benefits of the improved EPA/DHA fish oil blend.

To emulate a Mediterranean diet, Super Omega-3 provides a standardized olive fruit extract to deliver the polyphenol hydroxytyrosol, a powerful antioxidant that protects normal LDL from oxidation and counters dangerous free radicals.45-48 Research shows that a combination of olive oil and fish oil supplements helps with inflammation better than a placebo or fish oil alone.49 Therefore, Super Omega-3 provides the equivalent polyphenol content of 6 ounces of extra virgin olive oil.

Super Omega-3 provides a concentrated olive fruit extract standardized for hydroxytyrosol, tyrosol and oleuropein polyphenols. Research shows the value of oleuropein in favorably altering gene expression, delaying senescence in specialized skin cells, and helping maintain normal platelet activation.

For those with sensitive stomachs or who experience burping of regular fish oils, Super Omega-3 is also available enterically coated, so the softgel is not degraded in the stomach … but broken down and released in the small intestine.

Cognitex is formulated to take advantage of the latest developments and ingredients for cognitive health. The latest ingredient in the Cognitex formula is uridine-5’-monophosphate, a critical brain nutrient.13

Uridine-5’-monophosphate (UMP) is a basic building block of RNA and DNA as well as of phosphatides such as phosphatidylcholine that are critical to optimal brain function and the health of neuronal cell membranes. Naturally found in the milk of nursing mothers, UMP is essential for the growth and development of infant brains.14 Animal studies suggest that dietary supplementation with UMP may increase brain acetylcholine and phosphatide levels, and enhance some cholinergic functions.15,16

The Cognitex formula provides other critical extracts that support healthy brain function, such as blueberry standardized for both anthocyanins and pterostilbene.

Anthocyanins, found in blueberries, are considered one of nature’s most potent antioxidants and have demonstrated properties that extend well beyond suppressing free radicals.17,18 Research suggests that Pterostilbene, another blueberry constituent, may help maintain healthy lipid and glucose levels.19 Through their unique biological effects, anthocyanins may help support DNA structure.20

Phosphatidylserine (PS) is a crucial building block in the brain. In fact, brain tissues are especially rich in this nutrient. However, aging causes a decline in the PS content of cells throughout the body including brain cells, which can lead to cognitive decline. hosphatidylserine helps the brain use its fuel efficiently. By boosting glucose metabolism and stimulating production of acetylcholine, supplemental phosphatidylserine has been shown to improve the condition of patients experiencing age-associated memory impairment or cognitive decline.11,12 Thus, replacing this brain food is essential.

Cognitex contains a compound that mimics the naturally occurring PS in the brain. Sharp-PS® GOLD, fortified with omega-3 fatty acids, delivers PS to the brain to help maintain youthful cognitive function. These unique nutrients have been extensively studied and may be of tremendous benefit for the aging brain.12

The brain is a metabolically active organ that produces high levels of free radicals. These free radicals can bombard the cell membranes of neurons causing premature loss of function. Cognitex contains a number of phytonutrient-based antioxidants that work best in a lipid (fat) rich environment like the brain.

While antioxidant nutrients provide essential free radical protection, many have limited capacity once they have spared an electron to balance a free radical. Cognitex contains a novel rosemary extract that is rich in carnosic acid, which provides multi-step protection against free radicals in a process called the carnosic acid cascade.21 At each step of free radical interaction a new compound is formed, which in turn is a powerful antioxidant in itself.

Nutritional support for the brain can be challenging because the “blood-brain barrier” can keep out not only harmful substances but beneficial nutrients and drugs as well. Cognitex contains a grape seed extract called Leucoselect® Phytosome™. By pairing proanthocyanidins from grape seed extract with phosphatides from soy lecithin in the Phytosome™, the uptake and distribution to target tissues of the grape seed polyphenols is enhanced.

Once in the brain, the grape seed polyphenols trap dangerous hydroxyl free radicals that turn fat rancid. These fats make up the outer lipid membrane of trillions of brain cells. These polyphenols also protect blood circulation and oxygen flow by improving the tone and elasticity of blood vessels.22-24

High levels of procyanidins from grape seed extract do not ensure an extract is going to have a beneficial effect on the brain. Polyphenols with higher molecular weight cannot be absorbed. Leucoselect® Phytosome™ contains smaller size molecules for advanced neurological activity.

Taking dietary supplements can seem like an act of faith since we often cannot feel their effects. Cognitex provides a patented, nonstimulant phytonutrient called Sensoril®. Sensoril® is a proprietary standardized extract of ashwagandha (Withania somnifera), also known as “Indian ginseng,” which is used in Ayurvedic traditional medicine for boosting brain function and alleviating mental fatigue. Advanced extraction practices allow for a highly concentrated yet balanced brain nutrient. The effects can often be felt immediately with greater alertness and focus but without jitteriness.

Stress can be very damaging to the brain, especially memory function. Sensoril® also helps modulate cortisol secretion, which positively influences the stress response.25-27

Cognitex provides a NeuroProtection Complex onsisting of highly concentrated standardized extracts of hops, ginger, and rosemary that help suppress inflammatory cytokines.28-32

Brain cells, such as neurons, are fed by blood vessels. Some of these (for example, microcapillaries) can be so small that red blood cells carrying oxygen pass through them very inefficiently. Vinpocetine enhances blood flow by dilating blood vessels and reducing blood viscosity. Vinpocetine enhances cerebral metabolism by helping to maintain healthy blood flow, which enhances oxygen utilization.33

L-alpha glycerylphosphorylcholine (Alpha-GPC), a precursor to the neurotransmitter acetylcholine, is naturally present in all the body’s cells. A decline in acetylcholine levels coincides with advancing age and is a hallmark of neurodegeneration. Cognitex provides Alpha-GPC as a crucial building block for the production of acetylcholine in the brain.34,35 The safety and importance to life of Alpha-GPC is evidenced by its substantial presence in human breast milk.36,37 Proper acetylcholine function is essential to muscle control, sleep, and cognition. Alpha-GPC plays a key role in both the synthesis and the catabolic recycling of phospholipids. Alpha-GPC supplementation may result in enhanced phospholipid synthesis, including synthesis of the phosphoinositides available for signal transduction at central nervous system level.38

Pregnenolone is a neuroactive hormone that may be especially beneficial to the brain39-44 yet the body’s production of it declines with age.45

Ultra Natural Prostate formula has been upgraded numerous times so that it contains the most scientifically substantiated nutrients to help protect the prostate gland and maintain its healthy function. The latest formulation of Ultra Natural Prostate contains the following key ingredients:

• Standardized lignans. Standardized lignans from flax and the Norway spruce trees convert to enterolactone in the intestine, which is then absorbed into the bloodstream. Enterolactone has demonstrated anti-estrogen and anti-DHT effects that are of particular importance for the aging prostate gland.4-7
• 5-LOXIN® Boswellia extract. Published studies show that normal aging and poor diet cause increasing levels of a dangerous enzyme (5-lipoxygenase),8,9 which can affect prostate cells. 5-LOXIN® is a patented extract from the boswellia (Boswellia serrata) plant that has been shown to suppress 5-lipoxygenase and other pro-inflammatory factors.10-12
• Nettle root extract (Urtica dioica). Testosterone converts to estrogen at higher rates as men age. Prostate cells are sensitive to estrogen’s growth stimulatory effects. Nettle helps support prostate cells against excess estrogen levels.13
• Saw palmetto extract with DeepExtract™. A number of normal biological events in aging men affect prostate function and structure. Saw palmetto has been shown to interfere with DHT activity in the prostate, inhibit alpha-adrenergic receptor activity (to support normal urinary flow), and help control inflammatory actions in the prostate gland.14-16 DeepExtract™ is a patented, ultra-high pressure CO2 technology engineered to recover far greater amounts of bioactive, high-molecular weight fatty acids from the saw palmetto berry during the extraction process. The result is a superior formula containing key ingredients in higher concentrations than many other extracts.17
• Pumpkin seed oil extract. This supercritical extract from “medicinal” pumpkin seed oil enhances the composition of the free fatty acids found in saw palmetto, and therefore enhances its benefits.
• Pygeum. Normal aging results in levels of certain prostaglandins increasing in the prostate gland. Pygeum africanum extract helps suppress prostaglandin E2, keeping the prostate gland placid and promoting prostate comfort.18
• Beta-sitosterol is the most biologically active constituent of pygeum.19-24 A standardized pygeum extract plus beta-sitosterol from other plant sources is included in this formula to help maintain healthy prostate structure.
• Cernitin®. This European pollen extract has been shown to relax smooth muscle tone of the urethra, counteract DHT, and help regulate inflammatory reactions.25-28
• Boron. In addition to helping protect bones, this mineral has been shown to slow elevation of prostate-specific antigen (PSA) — seemingly a result of boron’s positive effect on the presence of protein-degrading enzymes in the prostate gland.29-32
• Lycopene. This carotenoid associated with the tomato’s red color helps maintain healthy DNA gene function in prostate cells.33-41

Ultra Natural Prostate formula provides scientifically validated standardized plant extracts that have been shown to promote healthy prostate function. No other prostate protection formula provides such a broad array of nutrients to support the multiple factors involved in maintaining a healthy prostate gland.