Curcumin is impressing scientists around the world with its remarkable multiple health benefits. Curcumin is a polyphenol present in the spice turmeric and was first used by Indians over 3,000 years ago in traditional Ayurvedic medicine. Modern science has found that curcumin has remarkable antioxidative, immunomodulatory, proapoptotic, hepatoprotective and antiangiogenic properties.68-73 Curcumin is also found to increase detoxifying enzymes and promote healthy DNA function.74-78

Studies have tied inflammation to overexpression of a protein molecule called nuclear factor-kappa B (NF-kappaB). NF-kappaB acts like a switch to turn on genes that produce the body’s inflammatory responses. Because NF-kappaB’s expression increases in aging adults, scientists have sought ways to modulate NF-kappaB and its effects in the body.

Curcumin has been shown to exert powerful inhibitory effects on NF-kappaB activation within the body.79 Curcumin inhibits overexpression of NF-kappaB. In addition, curcumin inhibits the metabolism of arachidonic acid, as well as activities of cyclooxygenase, lipoxygenase, and cytokines (interleukins and tumor necrosis factor).80,81

Other clinical trials suggest roles for curcumin in helping maintain healthy lipid profile, bowel, and joint functions.82.83 Curcumin can also help maintain normal healthy platelet function,84-87 and have immunomodulatory effects by inhibiting histamine release from mast cells.88 Other studies show curcumin’s potential for supporting healthy brain function and offering neuroprotection.89-95

Curcumin may effectively support pancreatic islet health.96,97 Curcumin’s multifaceted effects include protecting against estrogen-mimicking chemicals,98,99 protecting against damaging free radicals, and promoting normal cell cycle growth.

The turmeric extract in Super Curcumin with Bioperine® has been standardized to 95% curcuminoids and enhanced with the thermo-nutrient Bioperine® in order to ensure optimal quality, potency, and bioavailability.

Vitamin C, as ascorbic acid, is a water-soluble substance found in citrus fruits and green vegetables. It is an important antioxidant that protects the body from free radicals and fights oxidative stress,38-41 both of which threaten the immune system. In fact, a major immune-supporting activity of vitamin C is boosting glutathione levels in human lymphocytes,42 cells that make up about 25% of all white cells in the blood. Scientists have determined that the body needs high levels of vitamin C during periods of stress.43,44

Because humans do not manufacture vitamin C internally, it must be obtained through dietary sources or supplements. Few people realize, however, that vitamin C is a water-soluble nutrient that is quickly oxidized and excreted by the body,45 which limits its efficacy. Until now, those seeking to capture vitamin C’s optimal health benefits have had no choice but to consume it several times throughout the day.

Fortunately, a flavonoid antioxidant known as dihydroquercetin functions as a vitamin C “supercharger.” Studies demonstrate that dihydroquercetin acts to inhibit the oxidation of vitamin C, thereby helping maintain its concentration and recycle vitamin C throughout the body.46,47 This synergistic relationship between dihydroquercetin and vitamin C48 greatly enhances the efficacy of both molecules in the body’s organs and tissues. Vitamin C with Dihydroquercetin was formulated for those seeking to obtain optimal efficacy and antioxidant protection from a vitamin C supplement.

In ancient Greek mythology, the pomegranate represents life and regeneration.92 Its use as an herb dates back more than 3,000 years. But contemporary science has rediscovered the pomegranate’s surprising array of health benefits.

Numerous studies show that pomegranate is one of nature’s most powerful antioxidants93-98 and it helps regulate LDL oxidation. The remarkable effect of pomegranate in dealing with various problems makes one wonder whether there is more benefit to this fruit than just free radical suppression. One answer may lie in the fact that pomegranate is absorbed in the bloodstream far more efficiently than other fruit extracts. One study showed a pomegranate extract is 95% absorbed, which is far greater than any other polyphenol-containing fruit extract of its kind.99 Another reason pomegranate has displayed such incredible clinical findings is that it contains a unique polyphenol group called punicalagins. Punicalagins are the major players behind the pomegranate’s antioxidant capability. These pomegranate ellagitannins can metabolize into smaller, beneficial polyphenols such as ellagic acid.

In ancient Greek mythology, the pomegranate represents life and regeneration.92 Its use as an herb dates back more than 3,000 years. But contemporary science has rediscovered the pomegranate’s surprising array of health benefits.

Numerous studies show that pomegranate is one of nature’s most powerful antioxidants93-98 and it helps regulate LDL oxidation. The remarkable effect of pomegranate in dealing with various problems makes one wonder whether there is more benefit to this fruit than just free radical suppression. One answer may lie in the fact that pomegranate is absorbed in the bloodstream far more efficiently than other fruit extracts. One study showed a pomegranate extract is 95% absorbed, which is far greater than any other polyphenol-containing fruit extract of its kind.99 Another reason pomegranate has displayed such incredible clinical findings is that it contains a unique polyphenol group called punicalagins. Punicalagins are the major players behind the pomegranate’s antioxidant capability. These pomegranate ellagitannins can metabolize into smaller, beneficial polyphenols such as ellagic acid.

Standardized Pomegranate Juice Concentrate provides the polyphenol content of up to 12.3 ounces of pomegranate juice (or 24 pomegranates) in only one ounce, without the high sugar calories.

Melatonin releases from the pineal gland, reaching its peak at night to help maintain healthy cell division in tissues throughout the body. Secretion of melatonin declines significantly with age, as the pineal gland becomes calcified.68,69  Jet lag, shift work, and poor vision can disrupt melatonin cycles.

Melatonin keeps our circadian cycle in tune.70,71 Not only does this hormone work to maintain cell health, it appears to regulate a system of self-repair and regeneration.72,73 As melatonin diminishes with age, our biological functions are impaired.74,75 Melatonin also has strong antioxidant properties. It directly scavenges both hydroxyl and peroxyl free radicals, and it does so more effectively than most other antioxidants. It also greatly potentiates the efficiency of other endogenous and exogenous antioxidants.76 Melatonin is especially important for protecting cellular DNA against peroxynitrite damage by inhibiting peroxynitrite free radical reactions.77 Some research has found that melatonin increases the speed of falling asleep and adds to the quality of sleep in about 60% of people who use it.78-81

Natural Sleep contains both immediate and timed release melatonin along with sleep-enhancing nutrient co-factors.

Alpha-lipoic acid consists of two different forms (isomers) that have vastly different properties. The “R” form is the biologically active component (native to the body) that is responsible for lipoic acid’s phenomenal antioxidant effect. The “S” form is produced from chemical manufacture and is not very biologically active. Alpha-lipoic acid supplements typically consist of the “R” and “S” form in a 50/50 ratio. That means a 100 mg alpha-lipoic acid supplement is providing 50 mg of the biologically active “R” form.

The human body normally produces and uses the “R” form of lipoic acid. This active form, R-lipoic acid, significantly supports healthy inflammatory response58-60, is a potent free-radical scavenger and has been shown to be more potent than the combined “R” and “S” forms that ordinarily comprise alpha-lipoic acid supplements.61-68

Life Extension is continually searching for innovative nutritional technologies. Now, through dedicated research and development, the discovery of a newer form of R-lipoic acid is being seen as the “next-generation” antioxidant powerhouse.

Life Extension’s Super R-Lipoic Acid has demonstrated superior bioavailability, stability, and potency for a variety of health benefits. This breakthrough converts the biologically active “R” form of lipoic acid to sodium-R-lipoic acid, which, in a recent human study achieved 10–30 times higher peak blood levels than pure R-lipoic acid.69 Not only does this newer lipoic acid formulation reach higher peak blood levels,70 it also achieves them sooner, up to 12 times faster than R-lipoic acid, ensuring rapid uptake from the plasma into the tissues.69 A recent study showed that oral ingestion of Super R-Lipoic Acid reached peak plasma concentrations within just 10–20 minutes of supplementation.70

Unlike other forms of lipoic acid, Super R-Lipoic Acid is more stable in the body. The increased stability of this enhanced formulation is the reason for its greater absorption and bioavailability compared with R-lipoic acid.

The superior antioxidant effects of R-lipoic acid are already well known for supporting healthy mitochondrial function. Now, Super R-Lipoic Acid provides even more potent benefits for preserving youthful cellular energy levels.

Quercetin is a bioflavonoid that supports cellular health and function. In human cell culture studies, it has been shown to block the manufacture and release of inflammation-causing substances,153,154 which can help support a healthy immune response to the seasonally changing environment. It also helps promote a healthy cardiovascular system by preserving endothelial integrity155 and supporting healthy blood glucose levels for those already within normal range.156 Optimized Quercetin is a proprietary formulation that sets the “gold standard” for high-quality quercetin derived from a food-source blend.

Internally produced antioxidants — including the enzymes superoxide dismutase (SOD) and catalase — are the body’s primary defense against free-radical assault, offering up to thousands of times more protection against certain dangerous free radicals than dietary antioxidants.

The body’s supply of youthful antioxidant enzymes rapidly decreases with age.63,64 Fortunately, SODzyme® with GliSODin® & Wolfberry combines three advanced ingredients to help replenish the body’s supply of SOD, vastly enhancing its natural antioxidant defenses.

The first nutrient is SODzyme®, a proprietary plant-based extract. In a study of 12 middle-aged volunteers who took 2,000 mg of SODzyme® daily for two weeks, SODzyme® boosted serum SOD levels by 30% on average, and reduced toxic hydrogen peroxide by 47%.65

The second ingredient contained in this formula is GliSODin®, a patented, plant-derived form of SOD. In an animal study, small amounts of orally administered GliSODin® raised blood levels of SOD by 89% and increased catalase levels by 171%!66

The third ingredient provided is a standardized wolfberry (Lycium barbarum) fruit extract. Wolfberry is found to have the highest ORAC values of all fruits, and is effective in scavenging superoxide radicals and in preventing their formation. When given to patients aged 64–80, wolfberry increased blood levels of SOD by 48% and lowered dangerous blood lipid peroxides by 65% in only 10 days!67

Booster softgels contain nutrients that support arterial health and provide comprehensive protection from the effects of oxidative damage caused by free radical assaults. Like the Super Booster formula, Booster Softgels provide significant cost savings over purchasing each ingredient separately. This particular formula is still being offered because it does not contain vitamin K. Coumadin® (Warfarin) drug users are advised to avoid high-dose vitamin K supplements.

Berry Complete
"High-ORAC† Complex"
30 vegetarian capsules
Item Catalog Number: 01206

While thousands of published studies support the benefits of conventional antioxidants (like vitamins E and C), scientists have discovered that extracts from brightly colored fruits and vegetables possess far greater antioxidant capacity.32-39 In fact, human epidemiological studies show that those who regularly consume these potent plant-based anthocyanins and other polyphenols remain far healthier in their advanced years. If you’re not eating the recommended five servings of fruits and vegetables a day, especially the dark-skinned varieties, you could be lacking optimal antioxidant protection against toxic free radicals.

To measure the antioxidant strengths of food and other substances, scientists use an ORAC score.40 A higher score means that a particular food is better at protecting the body’s cells from free radical-induced damage. But problems with availability, freshness and cost mean that obtaining a wide variety of high-ORAC fruits and vegetables daily can be difficult.

So Life Extension® developed the Berry Complete formula to provide a concentrated blend of fruit and vegetable extracts with some of the highest ORAC scores around. Each capsule is packed with scientifically proven polyphenols and anthocyanins from seasonal and perishable fruits and legumes with the highest ORAC values. Just one capsule provides the antioxidant capacity of more than 50% of the daily recommended five-a-day intake of fruits and vegetables.